(1979) studied mouse-man hybrid rearrangements involving chromosome 11 and assigned the nonalpha-globin cluster to the region 11p11-p15. By 'liquid' molecular hybridization, Haigh et al. The order of the genes in the beta-globin cluster was proved by restriction enzyme studies ( Fritsch et al., 1979) starting with the 5-prime end, the order is gamma-G-gamma-A-delta-beta-Hpa I. Polymorphism was found at the third nucleotide of the codon for amino acid number 50 ( Wilson et al., 1977). (1978) found that the distance between the beta and delta genes is about 7,000 nucleotide pairs and that the delta gene is to the 5-prime side of the beta gene, as predicted by other evidence. Parallel experiments showed that the gamma globin genes (HBG1, 142200 HBG2, 142250) are also on chromosome 11, a result to be expected from other data indicating linkage of beta and gamma.įlavell et al. Use of a combination of somatic cell hybridization and hybridization of DNA probes permitted assignment of the beta hemoglobin locus to chromosome 11 ( Deisseroth et al., 1978). Sickle cell anemia (homozygous Hb SS 141900.0243) Hemolytic microcytic anemia in compound heterozygosity with Hb C (e.g. Congenital dyserythropoietic anemia (Irish type)
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